Rabeprazole in the treatment of acid-related disorders
نویسندگان
چکیده
Proton-pump inhibitors (PPIs) are widely used to treat acid-related disorders (ARD). Rabeprazole is a potent inhibitor of gastric H+/K+-ATPase, and it indicated for the treatment gastroesophageal reflux disease, Zollinger-Ellison syndrome, duodenal ulcers Helicobacter pylori eradication (in combination with antibiotics), as well ARD described in this article. Pharmacokinetic pharmacodynamic data show that rabeprazole provides marked acid inhibition from first administration, which persists repeated use. Due predominantly non-enzymatic metabolism, has lower interaction potential between drugs. Besides, maintains high intragastric pH achieves maximum 24 hours. characterized by linearity pharmacokinetics, remains unchanged renal hepatic insufficiency. available dosage form enteric capsules due PPIs instability an acidic environment. generally well-tolerated patients. Besides several minor side effects, safe be ARD. KEYWORDS: proton pump inhibitors, antisecretory drugs, rabeprazole, efficacy, safety, expediency, disorders, peptic ulcer, gastropathy, dyspepsia. FOR CITATION: Tsukanov V.V. disorders. Russian Medical Inquiry. 2023;7(5):264–273 Russ.). DOI: 10.32364/2587-6821-2023-7-5-4.
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ژورنال
عنوان ژورنال: RMŽ. Medicinskoe obozrenie
سال: 2023
ISSN: ['2686-9918', '2587-6821']
DOI: https://doi.org/10.32364/2587-6821-2023-7-5-4